Lentivirus internal

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Lentiviruses Internally

Lentiviruses Externally Lentiviral Capsid

Lentiviral particles--stepping inward

Proceeding inward, the viral matrix protein forms a layer inside the particle just under the lipid bilayer. The structure of this layer has been controversial. Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009). The movie below shows a MA hexamer (yellow) bound to a modeled membrane (green). Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange in Figure 1) assembled from monomers of the viral capsid protein (CA). The cone is a hollow "fullerene cone" built up from CA hexamers (second movie below, the CA hexamer is shown multicolored) assembled together with twelve CA pentamers (Ganser et al. 1999).