Difference between revisions of "Lentivirus internal"

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==Lentiviruses stepping inward==
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==Lentiviral particles--stepping inward==
  
Proceeding inward, the viral matrix protein forms a layer just under the lipid bilayer.  The structure of this layer has been controversial.  Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009).  Movie 2 shows an MA hexamer bound to a modeled membrane.
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Proceeding inward, the viral matrix protein forms a layer inside the particle just under the lipid bilayer.  The structure of this layer has been controversial.  Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009).  The movie below shows a MA hexamer (yellow) bound to a modeled membrane (green).
Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange) assembled from monomers of the viral capsid protein (CA).  The cone is a hollow "fullerene cone" built up from CA hexamers (Movie 3) assembled together with twelve CA pentamers (Ganser et al. 1999).
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Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange in Figure 1) assembled from monomers of the viral capsid protein (CA).  The cone is a hollow "fullerene cone" built up from CA hexamers (second movie below, the CA hexamer is shown multicolored) assembled together with twelve CA pentamers (Ganser et al. 1999).

Revision as of 20:30, 23 September 2011

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Lentiviruses Internally

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Lentiviruses Externally Lentiviral Capsid

Lentiviral particles--stepping inward

Proceeding inward, the viral matrix protein forms a layer inside the particle just under the lipid bilayer. The structure of this layer has been controversial. Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009). The movie below shows a MA hexamer (yellow) bound to a modeled membrane (green). Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange in Figure 1) assembled from monomers of the viral capsid protein (CA). The cone is a hollow "fullerene cone" built up from CA hexamers (second movie below, the CA hexamer is shown multicolored) assembled together with twelve CA pentamers (Ganser et al. 1999).