Difference between revisions of "Lentivirus internal"
From The HIV replication cycle a web-based interactive account
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− | == | + | ==Lentiviral particles--stepping inward== |
− | Proceeding inward, the viral matrix protein forms a layer just under the lipid bilayer. The structure of this layer has been controversial. Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009). | + | Proceeding inward, the viral matrix protein forms a layer inside the particle just under the lipid bilayer. The structure of this layer has been controversial. Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009). The movie below shows a MA hexamer (yellow) bound to a modeled membrane (green). |
− | Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange) assembled from monomers of the viral capsid protein (CA). The cone is a hollow "fullerene cone" built up from CA hexamers ( | + | Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange in Figure 1) assembled from monomers of the viral capsid protein (CA). The cone is a hollow "fullerene cone" built up from CA hexamers (second movie below, the CA hexamer is shown multicolored) assembled together with twelve CA pentamers (Ganser et al. 1999). |
Revision as of 20:30, 23 September 2011
Lentiviral particles--stepping inward
Proceeding inward, the viral matrix protein forms a layer inside the particle just under the lipid bilayer. The structure of this layer has been controversial. Figure 1 shows one proposal, hexagonal packing of MA trimers (yellow)(Alfadhli et al. 2009). The movie below shows a MA hexamer (yellow) bound to a modeled membrane (green). Lentivirus particles are distinguished by the presence of a bullet-shaped capsid (orange in Figure 1) assembled from monomers of the viral capsid protein (CA). The cone is a hollow "fullerene cone" built up from CA hexamers (second movie below, the CA hexamer is shown multicolored) assembled together with twelve CA pentamers (Ganser et al. 1999).