Difference between revisions of "HIV transcription"

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[[File:RelA.ogg|thumb|320x240px|The NFkappaB transcription factor.  The protein is encoded by the host cell but recruited by HIV to bind to the long terminal repeat DNA (LTR) and boost transcription.]]
 
[[File:RelA.ogg|thumb|320x240px|The NFkappaB transcription factor.  The protein is encoded by the host cell but recruited by HIV to bind to the long terminal repeat DNA (LTR) and boost transcription.]]
  
The proviral DNA contains all of the signals necessary to support transcription of the viral genome mediated by the host cell RNA polymerase II.  The viral long terminal repeat (LTR) binds a variety of cellular transcription factors, including the host cell encoded NFkappaB heterodimer (Nabel and Baltimore 1987)
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The proviral DNA contains all of the signals necessary to support transcription of the viral genome mediated by the host cell RNA polymerase II.  The viral long terminal repeat (LTR) binds a variety of cellular transcription factors, including the host cell encoded NFkappaB heterodimer <ref> [http://www.ncbi.nlm.nih.gov/pubmed?term=An%20inducible%20transcription%20factor%20activates%20expression%20of%20human%20immunodeficiency%20virus%20in%20T%20cells Nabel G, Baltimore D. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711-713.] </ref>
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Revision as of 15:15, 18 October 2011

« The HIV replication cycle: a web-based interactive account

HIV transcription

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The NFkappaB transcription factor. The protein is encoded by the host cell but recruited by HIV to bind to the long terminal repeat DNA (LTR) and boost transcription.

The proviral DNA contains all of the signals necessary to support transcription of the viral genome mediated by the host cell RNA polymerase II. The viral long terminal repeat (LTR) binds a variety of cellular transcription factors, including the host cell encoded NFkappaB heterodimer [1]



  1. Nabel G, Baltimore D. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711-713.