Reverse transcription

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Reverse transcription

Binding and entry: gp41 HIV integrase
HIV reverse transcriptase bound to DNA. The functional RT is composed of a heterodimer of p66 and p51 subunits. From coordinate file 3KLG.

Following entry, reverse transcription takes place, mediated by the viral encoded reverse transcriptase enzyme. Reverse transcription yields a DNA copy of the viral RNA [1] [2]

For review see: [3]

  1. Baltimore D. 1970. RNA-dependent DNA polymerase in virions of RNA tumor viruses. Nature 226: 1209-1211.
  2. Temin H, Mizutani S. 1970. RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus. Nature 226: 1211-1213.
  3. Hu W, Hughes SH. 2012. HIV: HIV-1 Reverse Transcription, in HIV From Biology to Prevention and Treatment, pp. 37 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.