Lentiviral proteins

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Lentiviral proteins

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Lentiviral particles The lentiviral envelope--gp120


Genes common to all Retroviruses

Name

Nature/function of protein

Abbreviated name (color)

Movie

gag

Group-specific antigen: Matrix

Forms matrix layer on particle membrane

MA (yellow)

gag

Group-specific antigen: Capsid

Forms capsid shell

CA (orange)

gag

Group-specific antigen: Nucleocapsid

Binds viral nucleic acid; nucleic acid chaparone

NC (red)

pro

Protease

Proteolytic cleavage of viral proteins

PR (purple)

pol

Polymerase: reverse transcriptase

Copies viral RNA into DNA, also RNAseH

RT (green)

pol

Polymerase: integrase

Initial DNA breaking and joining reactions mediating integration

IN (gold)

env

Envelope: gp120

Viral envelope protein: receptor binding

gp120 (cyan)

env

Envelope: gp41

Viral envelope protein: membrane spanning

gp41 (cherry)

Accessory/regulatory genes (unique to lentiviruses)

Name

Nature/function of protein

Abbreviated name (color)

Movie

tat

Transactivator of transcription

Promotes elongation of HIV transcripts

Tat (red )

rev

Regulator of virion

Promotes export of HIV RNA

Rev (pink)

vif

viral infectivity factor

Opposes inhibition by cellular APOBEC proteins

Vif (green)

vpr

viral protein R

Arrests cell cycle, promotes protein degradation

Vpr (violet)

vpx (HIV2 and SIV only)

viral protein x

Promotes degradation of cellular proteins

Vpx (grey)

nef

negative regulatory factor

Downregulates cellular CD4 and MHC I, promotes infectivity

Nef (brown)

vpu

viral protein u

Downregulates cellular BST2/tetherin

Vpu (blue-grey)