Integration in active transcription units

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Integration in active transcription units

HIV integrase Nucleosomes

Distribution of HIV integration sites on the human genome. Interactive browser

The preintegration complex then enters the nucleus and integrates into a chromosome of the host cell, most often within active transcription units. [1]

For review see: [2]

  1. Schroder ARW, Shinn P, Chen HM, Berry C, Ecker JR, Bushman F. 2002. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110: 521-529.
  2. Craigie R, Bushman FD. 2012. HIV DNA Integration, in HIV From Biology to Prevention and Treatment, pp. 59 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.