From The HIV replication cycle a web-based interactive account
Proceeding inward, the viral matrix protein forms a layer just under the lipid bilayer. The structure of this layer has been controversial. The image on the left shows one proposal, hexagonal packing of MA trimers (yellow) . The movie on the right shows an MA hexamer bound to a modeled membrane.
Hexagonal packing of MA trimers (yellow)
A matrix protein hexamer bound to a lipid bilayer membrane. Myristic acid residues on the amino-termini of the MA monomers intercalate into the membrane and stabilize binding. From structural studies of M. Summers and colleagues.
- ↑ Alfadhli A, Barklis RL, Barklis E. 2009. HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate. Virology 387: 466-472.