HIV matrix protein

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HIV matrix protein

The lentiviral envelope--gp120 HIV capsid protein

Proceeding inward, the viral matrix protein forms a layer just under the lipid bilayer. The structure of this layer has been controversial. The image on the left shows one proposal, hexagonal packing of MA trimers (yellow) [1]. The movie on the right shows an MA hexamer bound to a modeled membrane.

Hexagonal packing of MA trimers (yellow)
A matrix protein hexamer bound to a lipid bilayer membrane. Myristic acid residues on the amino-termini of the MA monomers intercalate into the membrane and stabilize binding. From structural studies of M. Summers and colleagues.

  1. Alfadhli A, Barklis RL, Barklis E. 2009. HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate. Virology 387: 466-472.