HIV and host factors

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HIV and host factors

Assembly and budding Lentiviral genomes

HIV replication cycle showing the action of several restriction factors

           In addition to the HIV-encoded proteins supporting HIV replication described above, a variety of host proteins are also recruited [1]. Studies yielding import host factors and tools for querying them are presented here [2]. [3] [4] [5] [6] [7] Other host cell proteins oppose HIV Infection (shown in red above).

  1. Zhou H, Xu M, Huang Q, Gates AT, Zhang XD, Castle JC, Stec E, Ferrer M, Strulovici B, Hazuda DJ et al. 2008. Genome-Scale RNAi Screen for Host Factors Required for HIV Replication. Cell host & microbe.
  2. Bushman FD, Malani N, Fernandes J, D'Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, Konig R et al. 2009. Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS pathogens 5: e1000437
  3. Jäger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ. 2011. Global landscape of HIV-human protein complexes. Nature 481(7381):365-70
  4. Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. 2008. GIdentification of host proteins required for HIV infection through a functional genomic screen. Science 319(5865):921-6
  5. König R, Zhou Y, Elleder D, Diamond TL, Bonamy GM, Irelan JT, Chiang CY, Tu BP, De Jesus PD, Lilley CE, Seidel S, Opaluch AM, Caldwell JS, Weitzman MD, Kuhen KL, Bandyopadhyay S, Ideker T, Orth AP, Miraglia LJ, Bushman FD, Young JA, Chanda SK. 2008. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135(1):49-60
  6. Malim MH, Bieniasz PD. 2012. HIV Restriction Factors and Mechanisms of Evasion, in HIV From Biology to Prevention and Treatment, pp. 119 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
  7. Telenti A, Johnson WE. 2012. HOst Genes Important to HIV Replication and Evolution, in HIV From Biology to Prevention and Treatment, pp. 409 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.