Binding and entry: gp120

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Binding and entry: gp120

The HIV replication cycle in cells Binding and entry: coreceptor
HIV gp120 protein bound to the CD4 receptor. From coordinate file 3JWD.

The HIV replication cycle begins with binding of a viral particle to a susceptible cell. The HIV gp120 on the viral particle binds to cellular CD4, explaining the tropism of HIV for CD4+ cells.

For review see: [1]

  1. Wilen CB, Tilton JC, Doms RW. 2012. HIV: Cell Binding and Entry. in HIV From Biology to Prevention and Treatment, pp. 23 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.