Binding and entry: coreceptor

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Binding and entry: coreceptor

Binding and entry: gp120 Binding and entry: gp41
The HIV co-receptor CXCR4. From coordinate file 3ODU.

The gp120 protein also binds to a second host encoded cell surface protein, which acts as a coreceptor, either CXCR4 [1] or CCR5 [2] [3] [4]

For review see: [5]

  1. Feng Y, Broder CC, Kennedy PE, Berger EA. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272: 872-877.
  2. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM, Berger EA. 1996. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955-1958.
  3. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM et al. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661-666.
  4. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149-1158.
  5. Wilen CB, Tilton JC, Doms RW. 2012. HIV: Cell Binding and Entry. in HIV From Biology to Prevention and Treatment, pp. 23 Cold Spring Harbor Laboratory Press, Cold Spring Harbor.